More than 100 Wellesley residents will be among the 6,500 riders this August at the 45^th Pan-Mass Challenge, the annual cycling fundraiser that contributes tens of millions for the Dana-Farber Cancer Institute.

The PMC boasts a variety of routes, including those that start and finish in Wellesley (at Babson College) and Foxborough.

The PMC, and those riders and volunteers who are undergoing or have undergone treatment for cancer, will be honored at this Friday night’s Red Sox game at Fenway Park.

Wellesley’s Jarrett Collins, Pan-Mass Challenge CEO, ready to celebrate fundraiser hitting the $1B mark

Among those from Wellesley taking part in the PMC, which takes place on Aug. 3 and 4, are father and son John and Michael Bueker. They signed up for the Sturbridge-to-Provincetown route, and each seeks to raise $6K.

“My dad and I are thrilled to be participating in this year’s Pan-Mass Challenge,” Michael says. “This event is not only an incredible opportunity to raise funds for the Dana-Farber Cancer Institute but also a special chance for us to spend time together. While this is my first PMC, it will be my dad’s second. We will be riding with Team Ropes & Gray. A donation of any amount or even a message of support would be greatly appreciated as we prepare for our ride in August!”

Another Wellesley rider, Anne Rickard Jackowitz, will be participating in her second PMC, doing the 85-mile route from Wellesley to Bourne. She’s riding for Team Heidi’s Heroes to support the fight against cancer and, more specifically, in support of Heidi Fischer and the hope for a cure for pancreatic neuroendocrine cancer.

“All my funds raised will be directed to support the lab of Dr. Jennifer Chan, who is the researcher at Dana-Farber who studies pancreatic neuroendocrine cancer,” Jackowitz explains on her fundraising page.

Jackowitz is riding in memory of her mom, who died at 64 from cervical cancer, and friend Carol Chaoui, died at the age of 56 after battling metastatic breast cancer. She also rides for “the many others who lost the fight or who continue to fight the fight in hopes for a cure.”